How Omega-3s Support Healthy Muscle
Jan 02th 2025

How Omega-3s Support Healthy Muscle

Written by
Laurel Sterling, MA, RD, CDN
Laurel is a registered dietitian-nutritionist and certified nutritionist and has worked in the natural products industry since 2000. She has a passion for empowering others through nutritional education.

Whether you're a seasoned athlete or someone just starting their fitness journey, understanding how to optimize muscle function is key. One often overlooked but powerful component in this equation is omega-3 fatty acids. Known primarily for their heart and brain benefits, these essential fats also play a significant role in enhancing muscle strength and performance.

Muscle function relies heavily on cellular health and inflammation management, and these are areas where omega-3s shine. These fatty acids integrate into cell membranes, improving fluidity and communication between cells which is critical during intense physical activity.

Moreover, they have been seen to balance inflammation. Clinicals studies have shown the beneficial effects of omega-3 fatty acids EPA and DHA, which compete with arachidonic acid for the enzymes responsible for the production of anti-inflammatory prostaglandins. EPA and DHA have been seen to block the production of inflammatory eicosanoids (thromboxanes, leukotrienes) thereby improving circulation, relaxing blood vessels, and lessening pain. All of this can assist exercise-induced inflammation, leading to faster recovery times and less soreness post-exercise.

Studies suggest that individuals supplementing with omega-3s experience greater increases in muscle strength compared to those who do not. Athletes may notice better endurance levels with improved blood flow and reduced fatigue through enhanced mitochondrial efficiency. Mitochondria are considered the powerhouse or the battery of cells as they are responsible for producing energy in the form of ATP (adenosine triphosphate). Beyond their role in energy production, mitochondria are involved in a range of vital processes including cell signaling, cellular differentiation, and the control of the cell cycle and growth. Studies show that “omega-3 supplementation positively impacts the composition of mitochondrial membranes and helps promote improvements in adenosine diphosphate (ADP) sensitivity”. ADP is formed when ATP loses one of its phosphate groups and thus releases energy, and it can be converted back to ATP when needed.

Research has also shown that omega-3s can enhance muscle protein synthesis, a process by which dietary protein is converted into muscle mass by activating specific pathways involved in building new proteins. In other studies omega-3 users showed an increase in lean muscle mass, decreased fat mass, an increase in resting metabolic rate, increased energy expenditure during exercise, and increased fat oxidation both during rest and exercise. Particularly important for aging populations, maintaining adequate omega-3 intake helps preserve existing muscle mass as many older adults face age-related muscle loss (Sarcopenia), and DHA alone may inhibit muscle degradation due to aging.

Adding omega-3s to your diet doesn't have to be complicated. Eat more fatty fish and aim for at least two servings per week of salmon, mackerel, sardines, or trout. The Mediterranean Diet has been repeatedly touted as the food plan to strive for as it has been shown to reduce incident frailty, fractures, hospitalizations, and deaths due to it being higher in antioxidants, omega-3s, and protein. If fish isn’t your thing, consider supplements. High-quality fish oil or algae-based supplements can be effective alternatives.

Omega-3 fatty acids are more than just a trend, they're a foundational element for anyone looking to boost their muscular health naturally. By integrating these essential nutrients into your lifestyle through diet and supplementation, you can unlock new levels of strength and endurance while promoting overall well-being. 

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