Although the exact cause of Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) is unknown, oxidative stress is believed to play a significant role in its development. Harvard researchers followed 957,740 adults for 10 years to determine whether various antioxidant supplements have a protective effect against ALS. Those who regularly consumed vitamin E supplements for 10 or more years prior to study commencement experienced a 62% reduction in risk of death from ALS. A 41% reduction in risk was also seen for persons using vitamin E supplements for less than 10 years. Although no specific dosages were reported, researchers estimated average intake to be approximately 400 IU. These results suggest that individual alpha tocopherol supplements may offer protection against developing ALS.
Ann. Neural 2005;57:104-10